Acanthosis nigricans is a brown to black, unsatisfactorily defined, velvety hyperpigmentation of the skin, usually begin at any age. AN most possibly is caused by factors which encourage epidermal keratinocyte and dermal fibroblast proliferation. In the benign form of AN, the factor is likely insulin or an insulinlike growth factor that inspires the epidermal cell propagation. Skin variations are the only signs of acanthosis nigricans. It is most often related with obesity. There are two basic types of acanthosis: benign and malignant. Though classically described as a sign of internal malignancy, this is very rare.
Acanthosis nigricans is conventionally characterized by hyperpigmented, velvety plaques of body folds. Acanthosis nigricans can affect differently healthy people, or it can be associated with clinical problems. Some cases are genetically congenital. It is most common among people of African declivity. The condition can also at times happen under the arms and in the groin.
Acanthosis nigricans is primarily a cosmetic concern. It is normally found in people with diabetes. This complication can occur in any breed secondary to other skin disorders, but the inherited primary form is seen almost exclusively in the dachshund. The malevolent form of AN is far less common, and, in one study, only 2 of 12,000 patients with cancer had signs of AN.
Most patients suffering from acanthosis nigricans have a higher insulin level than those of the same weight without acanthosis nigricans. Ennobled levels of insulin in most cases probably cause acanthosis nigricans. Obesity can result to acanthosis nigricans, as can many endocrine infirmities. Eating too much of the wrong foods, mainly starches and sugars, and being overweight can elevate insulin levels. There's no particular treatment - but treating any underlying conditions may cause the skin changes to fade.
Causes of Acanthosis Nigricans
The common causes and risk factor's of Acanthosis Nigricans involve the following:
- The veracious cause of this acanthosis nigricans is unknown.
- Acanthosis nigricans is sometimes related with being overweight.
- Specific medications - such as human growth hormone, oral contraceptives and large doses of niacin - can contribute to the condition.
- Rarely, acanthosis nigricans is correlated with certain types of cancer.
- Familial lipodystrophy of limbs and trunk.
- Genetic causes.
- Obesity can lead to acanthosis nigricans, as can many endocrine disorders.
- This may cause the featuristic skin changes.
Symptoms of Acanthosis Nigricans
Some sign and symptoms associated to Acanthosis Nigricans are as follows:
- Skin variations are the only signs of acanthosis nigricans.
- Latently, dark, velvety skin with very visible markings and creases appears in the armpits, groin, and neck.
- Occassionally, the lips, palms, soles of feet, or other areas may be affected.
- Skin tags often present in and around affected areas.
- Pruritus (itching) may be found.
Treatment of Acanthosis Nigricans
Here is list of the procedures for treating Acanthosis Nigricans :
- The most effective treatment is obtained through weight loss and exercise. Eating a healthy diet can help reduce circulating insulin and can lead to improvement, and occassionally resolution, of the skin problem.
- If you're concerned about the complexion of your skin, your doctor may prescribe a cream or lotion to help lighten the affected areas.
- Antibiotic ointments.
- Dermabrasion or laser therapy may help reduce the thickness of certain affected areas.
- Weight loss to lower insulin resistance.
- Other treatments to improve skin appearance, involving Retin-A, urea, alpha hydroxy acids, and salicylic acid prescriptions, may be helpful in some people.